Modern reproductive tech inits / SUN 9-25-22 / Sir Isaac Newton work on the fundamentals of light / Odd-numbered page typically / Opera whose title character is a singer / Rapper with the 2011 hit album Ambition / Weekend destination for an NYC getaway maybe / Opera that aptly premiered in Egypt

Constructor: Meghan Morris Relative difficulty: Medium-Challenging THEME: "Take Two" — you have to "take two" letter...